2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Adrenergic Receptor

Adrenergic Receptor

Beta Receptor

Adrenergic Receptor

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Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Isoform Specific Products:

Adrenergic Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108991
    T-0509
    		Agonist
    T-0509 ((-)-T-0509) is a selective full agonist of the β1 receptor. T-0509 activates the cAMP signaling pathway through the β1 receptor and enhances myocardial contractility.
    T-0509
  • HY-B1276A
    Metaproterenol
    		Agonist
    Metaproterenol (Orciprenaline) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol also has anti-inflammatory activity.
    Metaproterenol
  • HY-114814A
    (+)-ORM-10921 free base
    		Control
    (+)-ORM-10921 Free base is a compound that exhibits significant biological activity, particularly in the context of chemical synthesis studies and the preparation of pyrido [1,2-b] isoquinoline derivatives. (+)-ORM-10921 Free base is utilized as an active reagent in multi-component reactions involving alkynes and isoquinolinium ylides. (+)-ORM-10921 Free base plays a crucial role in the advancement of synthetic organic chemistry by enabling the formation of complex molecular structures.
    (+)-ORM-10921 free base
  • HY-W014726
    DL-Phenylephrine hydrochloride
    		Agonist
    DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.
    DL-Phenylephrine hydrochloride
  • HY-121398
    Dipivefrin
    		Agonist
    Dipivefrin is a potent adrenergic agonist. Dipivefrin is an adrenergic pro-agent. Dipivefrin can be used for reduce IOP (intraocular pressure) in patients suffering from chronic open angle glaucoma.
    Dipivefrin
  • HY-B1675
    Levalbuterol
    		Agonist
    Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.
    Levalbuterol
  • HY-107037
    Tolmesoxide
    		Antagonist
    Tolmesoxide (RX71107) is a peripheral vascular dilator with blood pressure lowering activity. Tolmesoxide has shown direct vasodilation in the human forearm arterial bed and dorsal hand vein. Tolmesoxide can dose-dependently increase blood flow in the forearm and produce dilation during contraction of the dorsal hand veins. Tolmesoxide can be used to study high blood pressure and angina.
    Tolmesoxide
  • HY-129955
    Carbazochrome salicylate
    Carbazochrome salicylate is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome salicylate is an antihemorrhagic agent.
    Carbazochrome salicylate
  • HY-117024
    Abediterol napadisylate
    		Agonist
    Abediterol napadisylate is an inhaled long-acting β2-adrenoceptor agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD).
    Abediterol napadisylate
  • HY-100980
    HEAT hydrochloride
    		Antagonist
    HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively.
    HEAT hydrochloride
  • HY-100699S
    Clenproperol-d7
    		Agonist
    Clenproperol-d7 is the deuterium labeled Clenproperol. Clenproperol is a β2-adrenergic agonist.
    Clenproperol-d<sub>7</sub>
  • HY-B0800R
    Guanethidine sulfate (Standard)
    Guanethidine (sulfate) (Standard) is the analytical standard of Guanethidine (sulfate). This product is intended for research and analytical applications. Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier.
    Guanethidine sulfate (Standard)
  • HY-119456A
    Romifidine hydrochloride
    		Agonist
    Romifidine hydrochloride is an α2 adrenergic receptor agonist. Romifidine hydrochloride shows sedation effects in vivo.
    Romifidine hydrochloride
  • HY-N0584B
    Anisodamine hydrochloride
    		Inhibitor
    Anisodamine hydrochloride is an anticholinergic and α1 adrenergic receptor antagonist. Anisodamine hydrochloride can be used for improving blood flow in circulatory disorders such as septic shock, Anisodamine hydrochloride displays a spectrum of pharmacological effects similar to Atropine (HY-B1205) and Sopolamine (HY-B2065) including inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion and urinary bladder contraction in vivo.
    Anisodamine hydrochloride
  • HY-P1376
    G-Protein antagonist peptide
    		Inhibitor
    G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
    G-Protein antagonist peptide
  • HY-163669
    ITI-333
    		Antagonist
    ITI-333 is a tetracyclic compound with oral bioavailability and analgesic activity, targeting multiple receptors. ITI-333 can be used for research on various forms of pain.
    ITI-333
  • HY-W759997
    Reproterol-d3
    Reproterol-d3 is the deuterium labeled Reproterol (HY-135490). Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research.
    Reproterol-d<sub>3</sub>
  • HY-B1486R
    Oxprenolol hydrochloride (Standard)
    		Antagonist
    Oxprenolol (hydrochloride) (Standard) is the analytical standard of Oxprenolol (hydrochloride). This product is intended for research and analytical applications. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.
    Oxprenolol hydrochloride (Standard)
  • HY-116790BSA
    (±)-Penbutolol-d9 hydrochloride
    		Antagonist
    (±)-Penbutolol-d9 (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM.
    (±)-Penbutolol-d<sub>9</sub> hydrochloride
  • HY-107326A
    Bunazosin hydrochloride
    		Antagonist
    Bunazosin hydrochloride is a potent and selective α1-adrenoceptor antagonist. Bunazosin hydrochloride can be used for antihypertensive and ocular hypotensive research.
    Bunazosin hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Adrenergic Receptor Isoform Comparison

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